Hot melt extrusion is one of the most used processing technologies inside the food, plastic and rubber industries. The process was industrialized in the late eighteenth century by an individual named Joseph Brama and made for the practice of manufacturing lead pipes. Sometime in the late 1850s, the technology has been introduced into the plastics industry and slowly to the rubber and food industries.
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Now, hot melt extrusion has found in pharmaceutical production and is now used for the production of various drugs such as pellets, granules, implants, ophthalmic inserts, and sustained-release tablets. Through hot melt extrusion, polymers could be shaped into a movie, doing away with the established solvent-cast practices.
The focus on hot melt extrusion by pharmaceutical manufacturers in the business is largely on the evolution of bio-enhanced formulas, forming solid solutions from water-soluble drugs and mass production of drugs in the shape of pellets, beads, and transdermal systems. There are both benefits and disadvantages of hot melt extrusion over more conventional drug manufacturing methods.
Where pharmaceutical production is concerned, hot melt extrusion provides a number of benefits over conventional manufacturing methods.
To start with, there are fewer steps required in the production of medication and there are no drying measures, which saves time and increases productivity. The process is straightforward and can be carried out continuously and efficiently.